A Functional Intronic Variant of <i>LILRB1</i> Associated With Clinical Malaria in the Senegalese Population
rs7246537 is a functional regulatory variant that reduces malaria susceptibility in Senegalese populations by modulating LILRB1 expression. These findings underscore the importance of non-coding variants and inhibitory immune pathways in malaria pathogenesis.
Authors
- Frédéric Gallardo (ORCID: https://orcid.org/0000-0002-8565-9730)
- Babacar Mbengué (ORCID: https://orcid.org/0000-0001-8953-409X)
- Pascal Rihet (ORCID: https://orcid.org/0000-0002-9459-3905)
- Alioune Dièye
- Gaël Chambonnier (ORCID: https://orcid.org/0000-0002-5606-2089)
- Alassane Thiam
- Magali Torres (ORCID: https://orcid.org/0000-0002-7760-3809)
- Christelle Dieppois
- Pascale Paul
Institutions
- Aix-Marseille Université (FR)
- Theories and Approaches of Genomic Complexity (FR)
- Institut Pasteur de Dakar (SN)
- Cheikh Anta Diop University (SN)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1093/infdis/jiag007
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00