Terrible APS — a newly defined variant of severe APS
We herein individualized a particularly refractory APS subcategory, TrAPS. The TrAPScore incorporates severe thrombocytopenia, heart valve disease, microvascular manifestations, and triple-positive serology. A TrAPS score >6 predicted a high likelihood of severe, refractory disease while effectively excluding TrAPS.
Authors
- Ronen Shavit
- Stanley Niznik (ORCID: https://orcid.org/0000-0002-9942-6313)
- Nancy Agmon‐Levin (ORCID: https://orcid.org/0000-0001-9514-3677)
- Shiri Weinstein
- Yulia Lifshitz
- Soad Haj Yehia
- Tania Zaher
Institutions
- Tel Aviv University (IL)
- St George's, University of London (GB)
- Sheba Medical Center (IL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fimmu.2025.1721515
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00