Modeling neurovascular dysfunction in Alzheimer’s disease using an isogenic brain-chip model
In this brain-chip model, we showed Aβ-independent NVU dysfunction that was related to neuroinflammation and vascular tau accumulation. This study demonstrates the utility of the brain-chip model to evaluate changes in NVU functions induced by AD-like pathology and highlights donor-specific responses associated with the use of hiPSC-derived models.
Authors
- Lorna Ewart (ORCID: https://orcid.org/0000-0002-8258-7460)
- Héctor Rosas-Hernández (ORCID: https://orcid.org/0000-0002-2736-8302)
- Katelin S. Matazel
- Andrew Shen
- Randy S. Daughters
- W. Drew Gill
Institutions
- National Center for Toxicological Research (US)
- Emulate (United States) (US)
Publication Details
- Journal
- Fluids and Barriers of the CNS
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s12987-025-00708-y
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Food and Drug Administration
- National Institute on Aging