Treatment of Multiple Myeloma: ASCO–Ontario Health (Cancer Care Ontario) Living Guideline
Daratumumab therapy may be offered to patients with high-risk smoldering myeloma. Quadruplet therapy with daratumumab or isatuximab, combined with bortezomib, lenalidomide, and dexamethasone, should be offered as initial therapy for transplant eligible patients. They should also be offered at least lenalidomide maintenance, with or without daratumumab, carfilzomib, and/or dexamethasone. Quadruplet therapy with daratumumab or isatuximab, combined with bortezomib, lenalidomide, and dexamethasone, should be offered as therapy for suitable transplant-ineligible patients. Patients with relapsed or refractory multiple myeloma should be offered triplet therapy or T-cell redirecting therapies according to a set of recommended principles.Additional information is available at www.asco.org/hematologic-malignancies-guidelines.
Authors
- Arleigh McCurdy (ORCID: https://orcid.org/0000-0002-8809-4368)
- Hans J. Messersmith (ORCID: https://orcid.org/0000-0002-4585-9906)
- Susan Bal
- Joseph Mıkhael (ORCID: https://orcid.org/0000-0001-9670-2864)
- Benjamin Avi Derman (ORCID: https://orcid.org/0000-0002-4070-1819)
- Samer S.A. Al Hadidi
- C. L. Costello
- Sita Bhella (ORCID: https://orcid.org/0009-0005-9553-4340)
- Raetasha Dabney
- Alan Langerak
- S. Latha
- Tanya M. Wildes (ORCID: https://orcid.org/0000-0002-1479-7626)
- Brea Lipe (ORCID: https://orcid.org/0000-0002-7596-2015)
- Shaleen Kumar
- Hira Mian (ORCID: https://orcid.org/0000-0003-1584-1067)
- Cynthia Chmielewski
- Rahul Seth
- Eloisa Riva
- Thomas Martin
- Lisa K. Hicks
- Rahul Banerjee
- Monique Hartley-Brown
Institutions
- Translational Genomics Research Institute (US)
- St. Michael's Hospital (CA)
- American Society of Clinical Oncology (US)
- New Jersey Department of Health (US)
- University of Alaska Anchorage (US)
- University of California, San Francisco (US)
- SUNY Upstate Medical University (US)
- Juravinski Cancer Centre (CA)
- Texas Oncology (US)
- Ottawa Hospital (CA)
- Princess Margaret Cancer Centre (CA)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- University of Chicago (US)
- Fred Hutch Cancer Center (US)
- United Way of Anchorage (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic in Arizona (US)
- Hospital de Clínicas (UY)
- Arizona Oncology (US)
- Moores Cancer Center
- University of Nebraska Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1200/jco-25-02587
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00