Cyclodextrin‐based delivery of Annexin A1 mimetic Ac2–26 enhances anti‐inflammatory effect and prevents dengue‐induced lethality combined with antiviral therapy
These findings underscore the therapeutic potential of anti-inflammatory/pro-resolving strategies in severe dengue and support the development of CDX-Ac<sub>2-26</sub> as a novel adjunctive treatment. Combining anti-inflammatory and antiviral approaches may enhance efficacy and reduce treatment-associated toxicity, offering a promising path for clinical translation.
Authors
- Pedro Pires Goulart Guimarães (ORCID: https://orcid.org/0000-0003-4534-2779)
- Angélica Samer Lallo Dias
- Viviane Lima Batista (ORCID: https://orcid.org/0000-0002-7821-9841)
- L P Sousa
- Felipe Emanuel Oliveira Rocha
- Leticia Soldati silva
- Jenniffer Ramos Martins (ORCID: https://orcid.org/0000-0002-2916-2631)
- Felipe Rocha da Silva Santos (ORCID: https://orcid.org/0000-0002-8392-1467)
- Ivana S. Lula (ORCID: https://orcid.org/0009-0006-3987-5738)
- Thiago Moreno L. Souza
- Ana Luiza de Castro Santos
- Laís G. Ramos (ORCID: https://orcid.org/0000-0001-8701-3514)
- Talita Fonseca
- Edvaldo S. Lara
- Vivian Vasconcelos Costa
- Mauro Martins Teixeira
- Celso Martins Queiroz‐Junior
- Jéssica Aparecida Barsalini Pereira
Institutions
- Universidade Federal de Minas Gerais (BR)
- National Institute of Science and Technology (ID)
- Fundação Oswaldo Cruz (BR)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1111/bph.70303
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- L'Oreal USA
- National Science Council
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais