Glutamate metabotropic receptor 4 in breast cancer: a potential and specific target for chimeric antigen receptor therapy
GRM4 emerges as a novel CAR-associated target for breast cancer, demonstrating tumor-specific overexpression, brain-restricted normal expression, and pan-subtype applicability with potential on-target off-tumor effect.
Authors
- Yien Xu
- Jundong Wu (ORCID: https://orcid.org/0000-0002-5268-2731)
- Zexiao Chen
- Wenjun Zhang
- Ayidana Hayierhan
- Ran Mei (ORCID: https://orcid.org/0009-0008-5376-2638)
- Yuhao Zhu (ORCID: https://orcid.org/0000-0001-5425-0986)
- Pingnan Sun
- Xiaoling Zhou
- Chaoliang Xu
- Yumei Ma
Institutions
- Shantou University (CN)
- Cancer Hospital of Shantou University Medical College (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
- Shantou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fonc.2025.1654977
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shantou University
- Shantou University Medical College