Nanochelate-based BCc1 delivery and its impact on key regulatory pathways in BALB/c breast cancer: An analysis of Beclin-1, ATG-4B, ATG-7, and mTOR expression
In summary, BCc1 nanomedicine demonstrates therapeutic potential in BC, in part through the modulation of autophagy pathways. The observed gene expression profile-characterized by <i>mTOR</i> suppression and <i>Beclin-1</i> upregulation alongside reduced <i>ATG-4B</i> and <i>ATG-7</i> expression-indicates a selective enhancement of autophagy initiation, coupled with alterations in autophagosome maturation. This nuanced modulation of autophagy may contribute to BCc1's anti-tumor activity and warrants further investigation into its stage-specific mechanistic effects in cancer therapy.
Authors
- Masoumeh Heshmati (ORCID: https://orcid.org/0000-0002-4440-0589)
- Mohammad Hassan Nazaran (ORCID: https://orcid.org/0000-0002-9413-2295)
- Somayeh Kalanaky (ORCID: https://orcid.org/0000-0003-1797-236X)
- Maryam Hafizi (ORCID: https://orcid.org/0000-0001-7417-6955)
- Fereshteh Moheb Afzali (ORCID: https://orcid.org/0009-0009-5676-5997)
- Ali Salimi (ORCID: https://orcid.org/0000-0001-6461-9679)
- Mehrdad Hashemi
- Saideh Fakharzadeh
- Mohammad Esmail Akbari
Institutions
- Islamic Azad University South Tehran Branch (IR)
- Iran University of Medical Sciences (IR)
- Islamic Azad University Medical Branch of Tehran (IR)
- Shahid Beheshti University (IR)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102418
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00