Remodeling of the cell membrane-associated protein pool affects adhesive membrane properties in filaggrin insufficient keratinocytes and impacts distinct cellular and organellar functions
We conclude that the alterations in different membrane compartments in filaggrin insufficiency are reflected in changes in keratinocyte functions of relevance to AD pathology, and strategies to target those could open up new therapeutic approaches.
Authors
- Paweł Kamil Serafin (ORCID: https://orcid.org/0000-0003-3535-8099)
- Adrian Kobiela (ORCID: https://orcid.org/0000-0002-8957-5366)
- Aleksandra Bogucka (ORCID: https://orcid.org/0000-0002-7750-7585)
- Reza Abouali (ORCID: https://orcid.org/0000-0003-1420-3354)
- Lilit Hovhannisyan (ORCID: https://orcid.org/0000-0003-4706-6202)
- Jorge Bernardino de la Serna (ORCID: https://orcid.org/0000-0002-1396-3338)
- Ellen H. van den Bogaard (ORCID: https://orcid.org/0000-0003-4846-0287)
- Felicja Gajdowska
- Danuta Gutowska-Owsiak
- Aniela Kosobucka
- Kamila Kitowska
- Anna Biernacka
- Rafał Sądej
- Jos P. H. Smits
- Xinwen Wang
- Mikołaj Klimczuk
- Aleksandra Małgorzata Siedlar
- Graham S. Ogg
- Amandine Hauer
Institutions
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- University of Gdańsk (PL)
- Lung Institute (US)
- Radboud Institute for Molecular Life Sciences (NL)
- MRC Weatherall Institute of Molecular Medicine (GB)
- MRC Human Immunology Unit (GB)
- Gdańsk Medical University (PL)
- Air Force Medical University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s12915-025-02499-y
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00