Hyperoside ameliorates lupus nephritis by suppressing AKT1-mediated PANoptosis in podocytes: integrating network pharmacology and experimental validation
This study reveals that AKT1-mediated podocyte PANoptosis is a key mechanism in LN and establishes Hyp as a promising therapeutic agent targeting this pathway. These findings provide a novel and clinically translatable strategy for LN treatment.
Authors
- Chuanbing Huang (ORCID: https://orcid.org/0000-0002-9144-6416)
- Ming Li (ORCID: https://orcid.org/0000-0001-8882-6613)
- Zhongfu Tang
- Lili Cheng
Institutions
- Anhui University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fphar.2025.1726254
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00