Green synthesis and biological evaluation of pyrazoloazepines employing Ag/Fe3O4/ZnO MNCs

In this research new derivatives of pyrazoloazepines was synthesized in high yields using multicomponent reaction of isatins, imin derivatives of alkyl bromides and activated acetylenic compounds in the presence of Ag/Fe3O4/ZnO magnetic nanocomposite (MNCs) as a high performance magnetic catalyst in ionic liquid at room temperature. The Ag/Fe3O4/ZnO magnetic nanocomposits (MNCs) were synthesized using 1-Octhyl-3-methyl imidazolium bromide ([OMIM]Br) as a stabilizer and soft template. Also, the catalytic activity of the Ag/Fe3O4/ZnO MNCs was evaluated in reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized nanocomposite (NCs) have high catalytic activity for organic pollutants within few seconds. Short time of reaction, high yields of product, easy separation of catalyst and products are some advantages of this procedure.