RVG-targeted extracellular vesicles loaded with echinatin attenuate dopaminergic neurodegeneration via the IGF-2/PI3K/Akt pathway in Parkinson’s disease mice
This study demonstrates that RVG-EVs@Echi represents a safe, noninvasive, and effective nanotherapeutic platform for targeted brain delivery in PD. By activating the IGF-2/PI3K/Akt/Nrf2 neuroprotective pathway and modulating the gut-brain metabolic axis, this targeted delivery system presents a highly promising and translatable strategy for the treatment of PD and other neurodegenerative diseases.
Authors
- Wenlong Zhang (ORCID: https://orcid.org/0000-0002-9654-260X)
- Xiaoqin Zhu (ORCID: https://orcid.org/0000-0003-0330-8230)
- Xingting Huang (ORCID: https://orcid.org/0009-0001-7265-4228)
- Tingting Gan
- Ziting Zhu (ORCID: https://orcid.org/0000-0002-0662-205X)
- Pingyi Xu
- Xiaolei Liang
- Yuchen Xiao (ORCID: https://orcid.org/0009-0007-8604-3042)
- Hui Shu
- Weiqing Huang
- Zongtang Xu
- Xiaoyun Huang
- Mingshu Mo
- Liuyan Ding
Institutions
- Xinjiang Medical University (CN)
- Guangdong Medical College (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Second Affiliated Hospital of Xinjiang Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s12951-025-03997-5
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 22.24