Refined target-mediated drug disposition modeling of the anti-tissue factor pathway inhibitor antibody MG1113 in cynomolgus monkeys and rabbits
The refined TMDD model better characterized the nonlinear pharmacokinetic and pharmacodynamic profiles of MG1113 across species by incorporating both targets and delayed absorption after s.c. dosing. This model enabled quantitative prediction of sTFPI-α suppression in relation to MG1113 dose and baseline target levels, supporting a rational dose selection for ongoing and future clinical studies.
Authors
- Jiyoung Kim (ORCID: https://orcid.org/0000-0003-3313-4294)
- MinSoo Lee
- WooIn Lee
- Yasunori Aoki (ORCID: https://orcid.org/0000-0002-5881-2023)
- S K Chung
- Yoo-Seong Jeong
- Heechun Kwak
- Seonyoung Byoun
Institutions
- Seoul National University (KR)
- Hanall Biopharma (South Korea) (KR)
- AstraZeneca (Sweden) (SE)
- Josai International University (JP)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fphar.2025.1745702
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Seoul National University
- National Research Foundation of Korea