Sibling Comparisons to Account for Confounding in Observational Studies

This JAMA Guide to Statistics and Methods explains how sibling analysis can be used to account for confounding in observational studies, using the example of a study on acid suppressants during pregnancy and risk of neuropsychiatric disorders in offspring.

Authors

Yu-Han Chiu
Brian Lee (ORCID: https://orcid.org/0000-0002-3592-8146)
Viktor H. Ahlqvist

Institutions

Aarhus University (DK)
Brown University (US)
Karolinska Institutet (SE)
Drexel University (US)

Publication Details

Journal: JAMA
Published: 2026-01-07
DOI: https://doi.org/10.1001/jama.2025.22234
Citations: 2
Primary Topic: Prenatal Substance Exposure Effects
Type: article
Field-Weighted Citation Impact: 82.44

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article

Sibling Comparisons to Account for Confounding in Observational Studies

Yu-Han Chiu, Brian Lee, Viktor H. Ahlqvist

Jan 7, 2026

2 citations

JAMA

Prenatal Substance Exposure Effects

82.44

article

Sibling Comparisons to Account for Confounding in Observational Studies

Yu-Han Chiu, Brian Lee, Viktor H. Ahlqvist

January 7, 2026article en

2 citations

Abstract

JAMAVol. 335(7)

Aarhus University (DK), Brown University (US), Karolinska Institutet (SE), Drexel University (US)

Openalex Percentile: Top 0%

Prenatal Substance Exposure Effects

82.44

DOI Source OpenAlex

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