Functional toll-like receptor 4 links endotoxin sensing to platelet priming in feline platelets
This study is the first to demonstrate functional TLR4 expression in feline platelets. Activation of TLR4 sensitizes platelets to AA by augmenting TxA<sub>2</sub> production and attenuating prostaglandin-dependent inhibitory pathways. These findings highlight a novel mechanism by which platelet TLR4 contributes to immunothrombosis and may promote thrombotic risk in cats.
Authors
- Claire Stuhlmann
- Cheyenne K. Chen
- Meg Shaverdian (ORCID: https://orcid.org/0009-0006-6724-8969)
- Nghi Nguyen
- Ronald H. L. Li
- Joshua A. Stern
Institutions
- North Carolina State University (US)
- University of California, Davis (US)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fvets.2025.1731802
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- EveryCat Health Foundation
- Center for Companion Animal Health, University of California, Davis