Advancing the use of artificial intelligence in health technology assessment activities: insights and next steps from the 2025 HTAi Global Policy Forum

The use of Artificial Intelligence (AI) in Health Technology Assessment (HTA) activities presents an opportunity to enhance the efficiency, accuracy, and speed of HTA processes worldwide. However, the adoption of AI tools in HTA comes with diverse challenges and concerns that must be carefully managed to ensure their responsible, ethical, and effective deployment. The 2025 Health Technology Assessment international Global Policy Forum (GPF) informed GPF members of the integration of AI into HTA activities, with a particular focus on the use of Generative AI (GenAI). With the overarching goal of illuminating and inspiring tangible outputs and actionable recommendations, the event brought together a diverse range of interest holders to explore the opportunities and challenges of AI in HTA. This article summarizes the key discussions and themes that informed the GPF outcomes, including trust, human agency, and risk-based approaches, culminating in a proposed set of priority next steps for the HTA community regarding the integration of GenAI. It also highlights insights into the current state of digital transformation within HTA organizations and the life sciences industry, providing insights into where the field stands and where it is heading.