Investigating the mechanisms of ageing and neuroinflammation in age-related hearing loss: A proteomic analysis

In conclusion, we predict that aging may hinder the microtubule transport pathway, affect the CAMS and acidic glycoprotein pathways, influence the differential expression of proteins, thereby leading to the occurrence and development of ARHL. After the inhibition of microglia, key proteins of the CAMS and acidic glycoprotein pathways appeared among the differentially expressed proteins, which suggests that aging may induce ARHL by affecting myelin stripping in microglia, ultimately promoting the development of ARHL.