Systematic analysis of anoikis-related genes identifies SRPX2-FAK/AKT-IL-6 axis in the progression and peritoneal metastasis of gastric cancer
This study proposes an anoikis based molecular classification of GC and develops both prognostic and diagnostic models for PM. It further reveals that SRPX2 driven anoikis resistance, mediated through the FAK/AKT-IL-6 axis, facilitates peritoneal metastasis. These findings provide new directions for prognostic assessment and therapeutic strategies in gastric cancer.
Authors
- Fanghai Han (ORCID: https://orcid.org/0000-0002-5587-4827)
- Dong Hou
- Fang Zheng (ORCID: https://orcid.org/0000-0002-2024-2424)
- Jianan Tan
- Shengning Zhou (ORCID: https://orcid.org/0009-0002-4537-8683)
- Jintao Zeng
- Mingtao Liang
- Yequan Xie
- Jinhao Yu
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fgene.2025.1736097
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00