Is Cooler Safer and More Advantageous? A Feasibility Study in Rabbits
Induced hypothermia during ACC provides significant protection against ischaemia-reperfusion injury by minimizing oxidative damage, preserving antioxidant capacity, and maintaining metabolic balance, thereby enhancing haemodynamic function post-surgery. This approach allows for safely extended ACC times, with a safety margin appearing to correspond to 30 minutes under hypothermia, facilitating complex aortic arch reconstructions and enabling safer surgical training. Clinical trials are warranted to confirm these findings in humans.
Authors
- Kivanc Inan
- Afsun Şahin (ORCID: https://orcid.org/0000-0002-5083-5618)
- Tarık Taştekin
- Sema USLU (ORCID: https://orcid.org/0000-0003-0670-9187)
- Emrah Şişli (ORCID: https://orcid.org/0000-0001-8927-4785)
- Sadettin Dernek (ORCID: https://orcid.org/0000-0002-0865-7694)
- Fatih Kar
- Dilek Burukoğlu Dönmez
- Dilek Çetinkaya
Institutions
- Kütahya Dumlupınar Üniversitesi (TR)
- Eskişehir City Hospital (TR)
- Eskişehir Osmangazi University (TR)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1093/ejcts/ezag012
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00