Multi‐tracer PET monitoring of an immunomodulatory therapy in 4R tauopathy: Evaluating a novel drug's impact on glial function and protein pathology

This study highlights the potential of monitoring immunomodulatory strategies to address the complex interplay between chronic neuroinflammation and protein aggregation in ND. If successful, these findings could inform the development of novel therapeutic approaches for AD and related disorders, bridging the gap between preclinical research and clinical application.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_104796
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Multi‐tracer PET monitoring of an immunomodulatory therapy in 4R tauopathy: Evaluating a novel drug's impact on glial function and protein pathology

E. Joseph, Lea H. Kunze, Rosel Oos, G. Palumbo et al.
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Multi‐tracer PET monitoring of an immunomodulatory therapy in 4R tauopathy: Evaluating a novel drug's impact on glial function and protein pathology

E. Joseph, Lea H. Kunze, Rosel Oos, G. Palumbo, Manvir Lalia, Svetlana Salomasova, Tim Bathe, Matthias Brendel
article en

Abstract

This study highlights the potential of monitoring immunomodulatory strategies to address the complex interplay between chronic neuroinflammation and protein aggregation in ND. If successful, these findings could inform the development of novel therapeutic approaches for AD and related disorders, bridging the gap between preclinical research and clinical application.

Alzheimer s & DementiaVol. 21(S2)
German Center for Neurodegenerative Diseases (DE), LMU Klinikum (DE), Dassault Systèmes (Germany) (DE), Munich Cluster for Systems Neurology (DE), Ludwig-Maximilians-Universität München (DE)
Good health and well-being
Openalex Percentile: Top 31%
Alzheimer's disease research and treatments
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