Multi‐tracer PET monitoring of an immunomodulatory therapy in 4R tauopathy: Evaluating a novel drug's impact on glial function and protein pathology
This study highlights the potential of monitoring immunomodulatory strategies to address the complex interplay between chronic neuroinflammation and protein aggregation in ND. If successful, these findings could inform the development of novel therapeutic approaches for AD and related disorders, bridging the gap between preclinical research and clinical application.
Authors
- E. Joseph
- Lea H. Kunze
- Rosel Oos
- G. Palumbo
- Manvir Lalia
- Svetlana Salomasova
- Tim Bathe
- Matthias Brendel
Institutions
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Dassault Systèmes (Germany) (DE)
- Munich Cluster for Systems Neurology (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104796
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00