Impact of CYP2C19*2 on Clopidogrel Response and Cardiovascular Outcomes in ST-segment elevation myocardial infarction Patients
Individuals carrying one or two non-functional CYP2C19*2 (rs4244285) alleles - GA and AA genotypes classified as intermediate and poor metabolizers, respectively- - showed a significant association with CVEs. Conversely, subjects with GG genotypes (normal metabolizers) had a significantly lower incidence of CVEs.
Authors
- Ali Montazeri (ORCID: https://orcid.org/0000-0002-5198-9539)
- Waheed Iqbal (ORCID: https://orcid.org/0000-0003-3755-8633)
- Sami Siraj
- Abdur Razaq
- Syed Tahir Shah
Institutions
- Khyber Medical University (PK)
- Khyber Teaching Hospital (PK)
- Ghent University (BE)
- Pharmaceutical Biotechnology (Czechia) (CZ)
Publication Details
- Journal
- Pakistan Journal of Medical Sciences
- Published
- 2026-01-05
- DOI
- https://doi.org/10.12669/pjms.42.1.12358
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00