Activity homogeneity: a measure for comparing time discretization and state quantization in ODE simulation

In this work, we introduce the concept of activity homogeneity in the solutions of ordinary differential equations (ODEs) and characterize it through a metric called Homogeneity Factor . This indicator quantifies the degree of similarity in the temporal evolution of the system state variables. We show that this measure can be related to the convenience of using classic numerical integration schemes or quantization-based methods such as Quantized State System (QSS) algorithms. The developed notions, which are also extended to systems exhibiting discontinuities, provide a theoretical argument that corroborates observations from previous works, indicating that QSS methods offer advantages when activity is heterogeneous, systems are sparse, and/or frequent discontinuities occur. The concepts are applied to two case studies: an advection-diffusion-reaction model and a spiking neural network. Theoretical predictions are compared with empirical results obtained through simulations using different numerical integration methods, confirming that the proposed metric consistently identifies the integration strategy that is more computationally efficient in practice.

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Publication Details

Journal
SIMULATION
Published
2026-01-07
DOI
https://doi.org/10.1177/00375497251392588
Primary Topic
Gene Regulatory Network Analysis
Type
article
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article

Activity homogeneity: a measure for comparing time discretization and state quantization in ODE simulation

Ernesto Kofman, Rodrigo Castro, Mariana Bergonzi
SIMULATION
Gene Regulatory Network Analysis
article

Activity homogeneity: a measure for comparing time discretization and state quantization in ODE simulation

Ernesto Kofman, Rodrigo Castro, Mariana Bergonzi
article en

Abstract

In this work, we introduce the concept of activity homogeneity in the solutions of ordinary differential equations (ODEs) and characterize it through a metric called Homogeneity Factor . This indicator quantifies the degree of similarity in the temporal evolution of the system state variables. We show that this measure can be related to the convenience of using classic numerical integration schemes or quantization-based methods such as Quantized State System (QSS) algorithms. The developed notions, which are also extended to systems exhibiting discontinuities, provide a theoretical argument that corroborates observations from previous works, indicating that QSS methods offer advantages when activity is heterogeneous, systems are sparse, and/or frequent discontinuities occur. The concepts are applied to two case studies: an advection-diffusion-reaction model and a spiking neural network. Theoretical predictions are compared with empirical results obtained through simulations using different numerical integration methods, confirming that the proposed metric consistently identifies the integration strategy that is more computationally efficient in practice.

SIMULATIONVol. 102(3)
Consejo Nacional de Investigaciones Científicas y Técnicas (AR), Centro Internacional Franco-Argentino de Ciencias de la Información y de Sistemas (AR)
Openalex Percentile: Top 94%
Gene Regulatory Network Analysis
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