Effects of Causal and Noncausal Components of Screening on Prostate Cancer Mortality: A Mediation Analysis from the Dutch, Finnish, and Swedish Centers of the European Randomized Study of Screening for Prostate Cancer
The reduced PCSM achieved by early PCa detection via PSA-based screening is caused by more favorable prognostic features and subsequent improved treatment outcomes. Our findings confirm that the observed results are a causal effect of screening.
Authors
- Kirsi Talala (ORCID: https://orcid.org/0000-0002-9705-9265)
- Jonas Hugosson (ORCID: https://orcid.org/0000-0002-2324-2817)
- Daan Nieboer (ORCID: https://orcid.org/0000-0002-4403-6537)
- Anssi Auvinen (ORCID: https://orcid.org/0000-0003-1125-4818)
- Rebecka Arnsrud Godtman (ORCID: https://orcid.org/0000-0003-2061-6550)
- Sebastiaan Remmers
- Monique J. Roobol
Institutions
- Tampere University of Applied Sciences (FI)
- Sahlgrenska University Hospital (SE)
- Erasmus MC (NL)
- Tampere University (FI)
- Cancer Society of Finland (FI)
- Erasmus MC Cancer Institute (NL)
Publication Details
- Journal
- European Urology Oncology
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.euo.2025.12.004
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00