Impact of the Use of Bacterial Lysates on the Quality of Life in Patients with Recurrent Tonsillitis

Background: Prevention of recurrent bacterial tonsillitis is an uprising issue to avoid the risk of serious complications, especially in low and middle-income countries. Aim: We aimed to evaluate the effectiveness of the use of bacterial lysate in the prevention of recurrent tonsillitis by studying its impact on the quality of life and evaluating the dynamics of microbiological indicators. Methods: A Randomized controlled clinical trial was conducted among a total of 150 pediatric patients with recurrent tonsillitis. They were allocated to either treatment group, which received bacterial lysates for 3 successive months, or the control group, which received only the standard treatment for tonsillitis (anti-inflammatory, antipyretics, and antibiotic as indicated. Patients were evaluated 6 months after the end of treatment and were compared for quality-of-life indicators and laboratory microbiological indicators. Results: Data showed significant improvement of quality of life indicators among the treatment group compared to the control group, particularly in terms of number of doctor visits, antibiotic use, school absence days, with better school achievement. Laboratory microbiological indicators significantly improved among both groups at the end of the study. Conclusion: Use of bacterial lysate can significantly improve the quality of life of patients with recurrent tonsillitis, with reduction of inflammation and infection rates thus reducing the need for surgical intervention.