Connectivity‐Metabolism Interplay in the Salience Network: Insights into Network‐Specific Dysfunctions in Frontotemporal Dementia

The disconnection between local FC and metabolism in the anterior insula (AI), coupled with disrupted intra-network communication within the SN, supports the hypothesis of insula being a primary target in FTD (Seeley, 2010). These findings indicate a critical role of FC/metabolism coupling in maintaining network integrity and suggests that its disruption may lead to progressive breakdown of the SN, contributing to the functional deficits characteristic of the disease.