Disulfidptosis-Induced Chondrocyte-Macrophage Crosstalk via GYS1/CCND1/NOD2 Axis Promotes Osteoarthritis Progression
Disulfidptosis in chondrocytes is associated with M1 macrophage immune infiltration and could drive OA progression. Mechanism genes like GYS1/CCND1/NOD2 have diagnostic potential and could be novel biomarkers and therapeutic targets for OA. These findings highlight the translational potential of targeting disulfidptosis-related pathways to improve OA management and patient outcomes.
Authors
- Y. Jonathan Zhang (ORCID: https://orcid.org/0000-0002-0120-8693)
- Yujiao Liu (ORCID: https://orcid.org/0000-0003-1040-4124)
- Xianyan Zeng
- Zhihui Wei (ORCID: https://orcid.org/0000-0001-9306-991X)
- Rong Gou (ORCID: https://orcid.org/0000-0002-2784-9114)
- Hong Xiang (ORCID: https://orcid.org/0000-0003-4896-1321)
- Qing Sun (ORCID: https://orcid.org/0000-0002-2423-7809)
- Mi Yang (ORCID: https://orcid.org/0000-0002-1975-3075)
- Gaohai Shao
- Yiming Qu
- Shuheng Dong
Institutions
- Ministry of Education (TH)
- Chongqing Cancer Hospital (CN)
- Hubei University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/jir.s568766
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00