Photocatalytic 3D skeletal editing of carboxylic acids <i>via</i> [4 + 1] cyclization for streamlined synthesis of unsaturated γ-lactams

Herein, we report a photocatalytic strategy for the three-dimensional skeletal editing of carboxylic acids via sequential deoxygenation. It converts structurally diverse carboxylic acids into biologically unsaturated γ-lactams.

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Publication Details

Journal
Organic Chemistry Frontiers
Published
2026-01-01
DOI
https://doi.org/10.1039/d5qo01548k
Primary Topic
Radical Photochemical Reactions
Type
article
Field-Weighted Citation Impact
0.00
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article

Photocatalytic 3D skeletal editing of carboxylic acids via [4 + 1] cyclization for streamlined synthesis of unsaturated γ-lactams

Xiaohong Li, Liangbin Huang, Jiahui Yu
Organic Chemistry Frontiers
Radical Photochemical Reactions
article

Photocatalytic 3D skeletal editing of carboxylic acids via [4 + 1] cyclization for streamlined synthesis of unsaturated γ-lactams

Xiaohong Li, Liangbin Huang, Jiahui Yu
article en

Abstract

Herein, we report a photocatalytic strategy for the three-dimensional skeletal editing of carboxylic acids via sequential deoxygenation. It converts structurally diverse carboxylic acids into biologically unsaturated γ-lactams.

Organic Chemistry FrontiersVol. 13(5)
South China University of Technology (CN)
Openalex Percentile: Top 94%
Radical Photochemical Reactions
DOISourceOpenAlex
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Photocatalytic 3D skeletal editing of carboxylic acids <i>via</i> [4 + 1] cyclization for streamlined synthesis of unsaturated γ-lactams — Xiaohong Li, Liangbin Huang, et al. · Organic Chemistry Frontiers (2026) | TGRS Research Map | TGRS