A systematic review of the impact of vaccine reactogenicity on willingness to accept influenza vaccination in adults

While side effects are frequently cited as reasons for non-vaccination, there is a dearth of high-quality studies specifically addressing the impact of reactogenicity on influenza vaccine willingness. Although most suggest a link between experienced reactogenicity and reduced future intention to vaccinate, heterogeneity in study design and quality precludes firm conclusions. Understanding the implications of reactogenicity is essential to inform strategies that improve coverage and guide intervention design.