Serum PLA2R-IgG4/PLA2R-IgG ratio dynamics reveal pathogenic autoantibody subclass switch during progression of PLA2R-associated membranous nephropathy
During the disease progression, EM stages were correlated with altered autoantibody IgG subclass profiles: early stages featured IgG1 or IgG3 autoantibodies, while late EM stages shifted to IgG4 predominance.
Authors
- Dacheng Chen (ORCID: https://orcid.org/0000-0002-6007-164X)
- T Mok Zhen
- Yunyun Liu (ORCID: https://orcid.org/0000-0002-3771-6462)
- Dan Zhou (ORCID: https://orcid.org/0000-0003-1217-844X)
- Dandan Liang
- Shaoshan Liang
- Yong Zhong
- Biao Huang
- C. Zeng
- Xiaodong Zhu
- Jing Tian
Institutions
- Zhejiang Chinese Medical University (CN)
- Nanjing University of Chinese Medicine (CN)
- Zhejiang Sci-Tech University (CN)
- Nanjing General Hospital of Nanjing Military Command (CN)
- National Clinical Research (US)
- CM Hospital (KR)
- Nanjing University (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1080/07853890.2025.2610874
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00