Urokinase Promotes Redundantly Intratubular C3a-Formation But Not ENaC-Driven Hypertension in DOCA/Salt Kidney Injury
While not essential for filtration barrier injury, glomerular filtration rate decline, and hypertension in DOCA-salt-induced kidney injury, uPA, through plasmin, generates anaphylatoxins with effects on specific cytokines.
Authors
- Marie Lykke Bach (ORCID: https://orcid.org/0009-0006-1475-2678)
- Sai Sindhu Thangaraj (ORCID: https://orcid.org/0000-0002-5543-838X)
- Yaseelan Palarasah (ORCID: https://orcid.org/0000-0002-9337-0232)
- Boye Lagerbon Jensen (ORCID: https://orcid.org/0000-0001-7607-213X)
- Camilla Enggaard (ORCID: https://orcid.org/0000-0002-7245-4453)
- Per Svenningsen (ORCID: https://orcid.org/0000-0001-6590-7103)
- Antonia Heinl
Institutions
- University of Southern Denmark (DK)
- University of Regensburg (DE)
Publication Details
- Journal
- Hypertension
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25050
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00