MBD3 deficiency decommissions the nucleosome remodeling and deacetylase complex and orchestrates the epigenetic regulation of gene expression to suppress neuroblastoma progression
Our data identify MBD3 and the NuRD complex as potential therapeutic targets in neuroblastoma, highlighting the critical role of epigenetic regulation in tumor maintenance. Targeting this pathway may offer a novel strategy to selectively impair neuroblastoma cell survival and improve outcomes.
Authors
- Jinhu Wang (ORCID: https://orcid.org/0000-0002-7749-2475)
- S. Wu
- Chen Chen (ORCID: https://orcid.org/0000-0003-2104-534X)
- Hui Shi (ORCID: https://orcid.org/0000-0002-6947-9668)
- Ting Y. Tao
- Qinfang Zhu
- Qiang Shu
- Bize Guo
Institutions
- Zhejiang Cancer Hospital (CN)
- Ministry of Agriculture (LV)
- Children's Hospital of Zhejiang University (CN)
- Hangzhou Cancer Hospital (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1093/neuonc/noaf297
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00