BF <sub>3</sub> ·Et <sub>2</sub> O-catalyzed dearomative spirocyclization of ynones for the synthesis of spirolactams and spirolactones
This study presents a BF<sub>3</sub>·Et<sub>2</sub>O catalyzed intramolecular cyclization reaction of ynones, enabling the efficient synthesis of spiro-heterocyclic compounds, such as spiro-γ-lactams and spiro-γ-lactones. This reaction enables the synthesis of diverse spirocyclic compounds under metal-free and mild conditions, exhibiting broad substrate compatibility and excellent yields.
Authors
- Kui Li (ORCID: https://orcid.org/0000-0001-8790-6419)
- Quanye Liu
- S. Chen
- Jingfu Zhu
- Yu Zhao (ORCID: https://orcid.org/0000-0002-2608-5044)
- Yu Cheng (ORCID: https://orcid.org/0000-0001-5528-2058)
- D. Q. Wu
- Wei Li
Institutions
- Hebei University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1039/d5ob01826a
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00