Hypericin alleviates cerebral ischemia/reperfusion injury by modulating endoplasmic reticulum stress

These findings demonstrate that hypericin confers significant neuroprotection against cerebral I/R injury by attenuating ER stress-mediated apoptosis and preserving neuronal integrity. Hypericin may represent a promising therapeutic candidate for ischemic stroke.

Authors

Tingting Li
Chao Wang

Publication Details

Journal: Frontiers in Pharmacology
Published: 2026-01-07
DOI: https://doi.org/10.3389/fphar.2025.1723495
Primary Topic: Natural Compound Pharmacology Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Hypericin alleviates cerebral ischemia/reperfusion injury by modulating endoplasmic reticulum stress

Tingting Li, Chao Wang

Jan 7, 2026

Frontiers in Pharmacology

Natural Compound Pharmacology Studies

article

Hypericin alleviates cerebral ischemia/reperfusion injury by modulating endoplasmic reticulum stress

Tingting Li, Chao Wang

January 7, 2026article en

Abstract

Frontiers in PharmacologyVol. 16

Good health and well-being

Openalex Percentile: Top 94%

Natural Compound Pharmacology Studies

DOI Open Access PDF OpenAlex

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Hypericin alleviates cerebral ischemia/reperfusion injury by modulating endoplasmic reticulum stress — Tingting Li, Chao Wang · Frontiers in Pharmacology (2026) | TGRS Research Map | TGRS