Higher-dosed clotting factor prophylaxis fails to reduce postpartum hemorrhage in women with von Willebrand disease: findings from the observational PRegnancy and Inherited bleeding DisordErS study
Increasing the third trimester VWF and FVIII cutoff to < 80 IU/dL and aiming for ≥ 150 IU/dL at delivery did not decrease severe PPH. More research is needed on optimal peripartum hemostatic prophylaxis in VWD.
Authors
- Anne de Vaan (ORCID: https://orcid.org/0000-0001-6980-0477)
- Hans Duvekot
- Jeroen Eikenboom (ORCID: https://orcid.org/0000-0002-3268-5759)
- Marjolein Peters (ORCID: https://orcid.org/0000-0001-8419-7944)
- Karin P. M. van Galen (ORCID: https://orcid.org/0000-0003-3251-8595)
- Saskia E.M. Schols (ORCID: https://orcid.org/0000-0003-2423-2829)
- Laurens Nieuwenhuizen (ORCID: https://orcid.org/0000-0002-0494-9374)
- Floor Heubel-Moenen (ORCID: https://orcid.org/0000-0002-3281-926X)
- Marieke C. Punt (ORCID: https://orcid.org/0000-0002-1891-5255)
- Anja BU Mäkelburg (ORCID: https://orcid.org/0000-0002-0450-0833)
- Kitty W.M. Bloemenkamp (ORCID: https://orcid.org/0000-0002-1377-4625)
- Titia A. Lely
- Annemieke Middeldorp
- Roger Schutgens
- Michiel Coppens
- Marieke Kruip
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Radboud University Medical Center (NL)
- Maastricht University (NL)
- Máxima Medisch Centrum (NL)
- Amsterdam University Medical Centers (NL)
- Wilhelmina Children's Hospital (NL)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1016/j.jtha.2025.11.038
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00