AlphaFold3 predictions of novel GLI-SUFU interfaces identify binding-defective SUFU missense variants from medulloblastoma and Gorlin Syndrome patients

AI-powered modeling plus experimental validation reveal new GLI-SUFU interfaces linked to cancer and congenital mutations.

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Publication Details

Journal
bioRxiv (Cold Spring Harbor Laboratory)
Published
2026-01-07
DOI
https://doi.org/10.64898/2026.01.06.698042
Primary Topic
Hedgehog Signaling Pathway Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

AlphaFold3 predictions of novel GLI-SUFU interfaces identify binding-defective SUFU missense variants from medulloblastoma and Gorlin Syndrome patients

Lee Bardwell, Umaima Arif, A. Jane Bardwell
bioRxiv (Cold Spring Harbor Laboratory)
Hedgehog Signaling Pathway Studies
article

AlphaFold3 predictions of novel GLI-SUFU interfaces identify binding-defective SUFU missense variants from medulloblastoma and Gorlin Syndrome patients

Lee Bardwell, Umaima Arif, A. Jane Bardwell
article en

Abstract

AI-powered modeling plus experimental validation reveal new GLI-SUFU interfaces linked to cancer and congenital mutations.

bioRxiv (Cold Spring Harbor Laboratory)
University of California, Irvine (US)
Openalex Percentile: Top 94%
Hedgehog Signaling Pathway Studies
DOIOpen Access PDFOpenAlex
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