A novel, experimental design to assess rapid antidepressant action: Results from a phase 1b randomized trial of NV-5138
The innovative design of this exploratory study facilitated appropriate participant selection and rapid antidepressant response detection. These features may be useful in other trials evaluating RAADs (ClinicalTrials.gov, NCT03606395).
Authors
- Gerard Sanacora (ORCID: https://orcid.org/0000-0003-3722-8829)
- Andrea E. Formella (ORCID: https://orcid.org/0000-0003-2737-7898)
- Steven D. Targum (ORCID: https://orcid.org/0000-0003-1054-5197)
- Randall Owen
- Gianpiera Ceresoli-Borroni
Institutions
- Yahoo (United Kingdom) (GB)
- Chesapeake College (US)
- Yale University (US)
- Supernus Pharmaceuticals (United States) (US)
Publication Details
- Journal
- Journal of Psychiatric Research
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1016/j.jpsychires.2026.01.006
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00