METTL4 enhances GLI1 translation through m6Am modification to promote tumor progression as a therapeutic target for hepatocellular carcinoma
Our findings highlight the role of METTL4-mediated m<sup>6</sup>Am modification in promoting HCC progression by enhancing GLI1 translation. Targeting METTL4 with siMETTL4-Nanoparticles represents a novel therapeutic strategy, bridging molecular insights in RNA epitranscriptomics with translational applications for HCC treatment.
Authors
- Yihang Yuan (ORCID: https://orcid.org/0009-0008-4370-0660)
- Jianqing Chen
- Zishu Wang (ORCID: https://orcid.org/0000-0002-3641-3734)
- Y. Li
- Xuanfu Xu
- Dengyu Han
- Weijie Sun
- Qian Qiu
- Chaobo Chen
- Weiqi Dai
- Wenhui Mo
- Yuqi Liu
- Jiaojiao Chen
Institutions
- University of Shanghai for Science and Technology (CN)
- Anhui Medical University (CN)
- Nanjing Drum Tower Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
- Wuxi People's Hospital (CN)
- YangPu Geriatric Hospital (CN)
- Yangpu Hospital of Tongji University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.jare.2026.01.009
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00