Integrative Human Genomic and Pharmacological Analyses Identify <scp>CACNB4</scp> as a Druggable Target for Periodontitis
Through MR analysis, we identified CACNB4 as a potential druggable gene for periodontitis. Among the drugs targeting CACNB4, verapamil and safinamide emerged as the most promising candidates for periodontitis treatment. Pharmacological studies further demonstrated that these agents may inhibit osteoclast differentiation by targeting CACNB4, thereby offering potential therapeutic options for periodontitis.
Authors
- XiaoMeng Liu
- Hongjiao Li
- Yue Jiang (ORCID: https://orcid.org/0000-0003-0024-0605)
- Zhengyu Guan
- Xiu Yao
- B F Sun
- Dan Qiu
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- XinHua Hospital (CN)
- Shanghai Stomatological Hospital (CN)
- Ningxia Medical University (CN)
Publication Details
- Journal
- Journal of Periodontal Research
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1111/jre.70073
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00