Metal- and photocatalyst-free CF <sub>3</sub> -modification of <i>N</i> -containing fusion skeletons in photo-flow chemistry
Herein, we present an external photocatalyst-free protocol for the synthesis of trifluoromethylated, nitrogen-containing fused-ring scaffolds under photo-flow conditions. Based on a series of mechanistic studies, we propose two plausible reaction pathways that highlight the interaction between the substrate and the trifluoromethylating reagent.
Authors
- Yuchen Zhu (ORCID: https://orcid.org/0000-0002-7432-7837)
- Wen Lin
- Wenyi Wang (ORCID: https://orcid.org/0000-0003-0617-9438)
- Yunfeng He (ORCID: https://orcid.org/0000-0002-9951-3919)
- Chenxi Gu (ORCID: https://orcid.org/0009-0008-4442-3925)
- Jianjun Li (ORCID: https://orcid.org/0000-0002-3485-5379)
- Ting Lv
- Xingyi Zhu
Institutions
- State Key Laboratory of Chemical Engineering (CN)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1039/d5cc06603d
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00