Identifying Physiological and Cognitive Indicators of Subthreshold Depression and Major Depressive Disorder Progression Risk
StD correlates with physiological and cognitive abnormalities reflecting MDD, and persistent symptoms suggest increased progression risk. These findings present candidate markers (voice arousal, HRV, body temperature, emotion recognition) for early identification and risk stratification; however, conclusions should be interpreted cautiously given the exploratory design.
Authors
- Yasumasa Okamoto
- Satoshi Yokoyama (ORCID: https://orcid.org/0000-0002-1309-1103)
- Alan S. R. Fermin
- Yuki Mitsuyama (ORCID: https://orcid.org/0000-0001-8419-564X)
- Koki TAKAGAKI
- Yuri Okamoto
- Toshi A Furukawa
- Go okada
- Junichiro Yoshimoto
- Keisuke Mizoi
- Ayaka Shimizu
Institutions
- Hiroshima University (JP)
- Fujita Health University (JP)
- Kyoto University (JP)
- Niigata University (JP)
Publication Details
- Journal
- Neuropsychiatric Disease and Treatment
- Published
- 2026-01-01
- DOI
- https://doi.org/10.2147/ndt.s526034
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- JST-Mirai Program