Duhuo Jisheng decoction alleviates knee osteoarthritis via synovial mesenchymal stem cell-derived exosomes mediating the microRNA-194-5p/wnt signaling pathway
DHJSD not only enhances SMSCs proliferation and chondrogenic differentiation, but also stimulates chondrocyte activity via DHJSD-Exo mediated activation of the miR-194-5p/Wnt signaling pathway, offering promising insights into KOA treatment. Future research should focus on advancing these promising insights toward clinical application, through further mechanistic exploration, translational studies, and ensuring the consistency of the multi-herbal formula.
Authors
- Xiaoyun Li (ORCID: https://orcid.org/0000-0003-4706-6114)
- Ronghua Zhang (ORCID: https://orcid.org/0000-0001-9667-3303)
- Jiajia Huang (ORCID: https://orcid.org/0000-0002-7210-4840)
- Honghao Huang (ORCID: https://orcid.org/0000-0002-6337-9631)
- Shancheng Zhao (ORCID: https://orcid.org/0000-0002-8835-5628)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Qing Lin (ORCID: https://orcid.org/0000-0003-4889-443X)
- Xiaofeng Zhu
- Biyi Zhao
- Weipeng Sun
- Cong Lei
Institutions
- Jinan University (CN)
- Guangzhou University (CN)
- Key Laboratory of Guangdong Province (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1016/j.jep.2025.121140
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00