Decoding HSP90AA1-driven inflammatory signaling in the uveal melanoma microenvironment: an integrated analysis at single-cell resolution

By integrating computational biology screening and single-cell resolution analysis, this study successfully decodes HSP90AA1 as a key regulator of the UVM inflammatory and immune microenvironment. These findings, grounded in single-cell insights and confirmed by rigorous experimental validation, reveal the tumor's intrinsic "chaperone dependency" and highlight HSP90AA1 as a highly promising therapeutic target. Targeting HSP90AA1 may offer a new strategy for modulating the UVM tumor immune microenvironment and overcoming tumor progression.