Danggui-Shaoyao-San modulates sphingolipid metabolism to promote oligodendrocyte differentiation and maturation in vascular dementia rats
DSS improved VaD cognitive impairment by modulating sphingolipid metabolism and promote myelin regeneration via activating the SPHK2/S1P/S1PR5 signaling pathway. This study provides important experimental evidence for the clinical application of DSS in VaD.
Authors
- Yue Su (ORCID: https://orcid.org/0000-0002-7673-5789)
- Yuying Zhong (ORCID: https://orcid.org/0009-0003-1690-8371)
- Ningning Yuan
- Yafeng Zhang (ORCID: https://orcid.org/0000-0002-9965-9934)
- Xiaolan Cheng
- Mengmeng Huang
- Ying Xu
- Xiang Li
- Hui Yang
Institutions
- Nanjing University of Chinese Medicine (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1186/s13020-025-01284-x
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00