Role of Human Papillomavirus (HPV) Infection in Semen and Its Impact on Male Infertility in Qena Governorate, Upper Egypt

B Background: Human papillomavirus (HPV) is a common sexually transmitted virus implicated in male infertility, has been implicated in impaired sperm quality and male infertility. Despite growing evidence, its role in infertility remains unclear. Objectives: To evaluate the presence of anti-HPV IgG antibodies in semen of infertile men with genital warts and assess their impact on semen parameters. Patients and methods: This cross-sectional study was conducted at Qena University Hospital on 30 infertile men with genital warts and 15 age-matched fertile men. Semen samples were analyzed per WHO guidelines. All cases were subjected to history taking, clinical examination and semen analysis. Anti-HPV IgG was measured in seminal plasma via ELISA. Results: Sperm motility (total and progressive) was significantly reduced in HPV positive patients (p < 0.0001). Anti-HPV antibody levels showed no significant association with semen parameters. Conclusion: HPV positivity in semen correlates with impaired sperm motility in infertile men, suggesting a possible role of HPV in male infertility.