Insights into the taste of organic acids via TAS1Rs
Organic acids may elicit TAS1R3-dependent post-ingestion signals that contribute to enantiomer-selective consumption in mice. Electrostatic interactions and hydrogen-bonding networks within the orthosteric pocket of TAS1Rs may account for the differences in binding affinity to the LBD of medaka Tas1r2a/Tas1r3 between organic acids and L-alanine, a known ligand.
Authors
- Katsuki Takebe (ORCID: https://orcid.org/0000-0002-1611-1042)
- Yuko Yamase
- Atsuko Yamashita (ORCID: https://orcid.org/0000-0002-8001-4642)
- Ryusuke Yoshida
- Kengo Horie
- Yoshihiro Mitoh
Institutions
- Okayama University (JP)
- Protein Research Foundation (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1016/j.job.2025.100731
- Primary Topic
- Biochemical Analysis and Sensing Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00