Recombinant klotho protein protects tissues by mitigating the detrimental effects of sterile inflammation following hemorrhagic shock
rKL attenuates tissue injury following HS by reducing ROS, apoptosis, and inflammation, as well as modulating macrophage polarization. These findings suggest that rKL may serve as a promising adjunctive therapeutic strategy for improving HS outcomes.
Authors
- Jaewon Beom (ORCID: https://orcid.org/0000-0001-7984-9661)
- Yoo Seok Park (ORCID: https://orcid.org/0000-0003-1543-4664)
- Youngbin Park (ORCID: https://orcid.org/0000-0003-1949-4568)
- Sojung Lee (ORCID: https://orcid.org/0000-0002-2519-8442)
- Je Sung You
- Yong Eun Chung
- Ji Sun Woo
Institutions
- Emory University (US)
- Yonsei University (KR)
- Republic of Korea Army (KR)
Publication Details
- Journal
- Shock
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1097/shk.0000000000002755
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00