Mechanism of ultrasound-guided renal parenchymal injection of MSCs for the treatment of chronic kidney disease: down-regulated SGK1 promotes M2 macrophage polarization
Ultrasound-guided MSCs injection into the renal parenchyma provides an efficient and precise therapeutic approach for CKD. MSCs promote macrophage M2 polarization and exert anti-fibrotic effects in CKD by downregulating SGK1 expression.
Authors
- Daiyuan Tang (ORCID: https://orcid.org/0000-0001-6610-4310)
- Long Hu (ORCID: https://orcid.org/0000-0003-2976-3709)
- Changxing Ke
- Fen Bao
- Yingqing Zeng
- Chunjuan Xia
- Shanshan Wan
- Zuozhang Yang
- Jiaping Wang
- Liangyu Zhu
Institutions
- Kunming Medical University (CN)
- Qujing Normal University (CN)
- Ningbo University Affiliated Hospital (CN)
- Xijing Hospital (CN)
- Ningbo First Hospital (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s40001-025-03724-8
- Citations
- 1
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 34.94