PARP1 trapping activates cGAS-STING pathway to induce immunogenic cell death in multiple myeloma
Taken together, our findings indicate that Alt-NHEJ inhibitors are potential immune-stimulating agents for MM with hyperactivation of cGAS-STING pathway, coherently with our working hypothesis.
Authors
- Domenica Ronchetti (ORCID: https://orcid.org/0000-0002-4824-3445)
- Stefania Signorelli
- Antonio Galvano (ORCID: https://orcid.org/0000-0003-4365-5683)
- Elisa Taìana (ORCID: https://orcid.org/0000-0003-4940-1318)
- Nicoletta Polerà (ORCID: https://orcid.org/0000-0002-0636-0774)
- Giada Juli (ORCID: https://orcid.org/0000-0002-5317-6144)
- Daniele Caracciolo (ORCID: https://orcid.org/0000-0001-7870-7565)
- Pierfrancesco Tassone
- Sara Squillacioti
- Anna Maienza
- Michelangelo Vocaturo
- Pierosandro Tagliaferri
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Magna Graecia University (IT)
- Institute for Biomedical Research and Innovation (IT)
- University of Palermo (IT)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1186/s12935-025-04152-8
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00