Treatment of patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplantation: position statement of the Myeloma Foundation of Australia Medical and Scientific Advisory Group
Patients with newly diagnosed multiple myeloma and considered transplant ineligible (TIE) because of age, frailty and/or comorbidities now have access to highly effective therapies that can achieve deep and/or durable remission. TIE patients are a highly heterogeneous population whose biological and chronological age can vary substantially. The treatment of these patients can be challenging in clinical practice and requires a frailty-adapted, individualised approach with an emphasis on treatment deliverability and tolerability to optimise patient outcomes. Here, we summarise recommendations for TIE patients, including pre-treatment considerations, induction and maintenance therapies, and supportive care management.
Authors
- Silvia Ling (ORCID: https://orcid.org/0000-0001-9739-7101)
- Andrew C.W. Zannettino (ORCID: https://orcid.org/0000-0002-6646-6167)
- N Weber (ORCID: https://orcid.org/0000-0001-6341-2537)
- Cindy H. Lee (ORCID: https://orcid.org/0000-0002-8296-9362)
- Georgia J. B. McCaughan (ORCID: https://orcid.org/0000-0002-4838-9022)
- Dipti Talaulikar (ORCID: https://orcid.org/0000-0001-6766-8345)
- Angelina Yong
- Shirlene Sim (ORCID: https://orcid.org/0000-0001-5577-444X)
- D. E. Joshua
- Peter N. Mollee (ORCID: https://orcid.org/0000-0002-8537-1198)
- Simon James Harrison (ORCID: https://orcid.org/0000-0003-4555-6582)
- Bradley Augustson
- Andrew Spencer
- P. Joy Ho
- Hang Quach
- H. Miles Prince
- Anna Kalff
Institutions
- Australian National University (AU)
- The University of Sydney (AU)
- Royal Adelaide Hospital (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- University of South Australia (AU)
- Royal Brisbane and Women's Hospital (AU)
- Royal Prince Alfred Hospital (AU)
- Epworth Hospital (AU)
- Peter MacCallum Cancer Centre (AU)
- Liverpool Hospital (AU)
- Princess Alexandra Hospital (AU)
- The Alfred Hospital (AU)
- Sir Charles Gairdner Hospital (AU)
- UNSW Sydney (AU)
- St Vincent's Hospital Melbourne (AU)
- St Vincent's Hospital Sydney (AU)
- Mental Health Australia (AU)
- Act Health (AU)
- Monash University (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- Internal Medicine Journal
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1111/imj.70329
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00