Lewis acid-switched regiodivergent <i>N</i> <sup>1</sup> / <i>N</i> <sup>2</sup> -alkylation of ben-zotriazoles with α-hydroxyl diazo compounds
Herein, we report a Lewis acid-switching strategy that enables programmable selectivity between kinetically controlled <i>N</i><sup>1</sup>-alkylation and thermodynamically favored <i>N</i><sup>2</sup>-alkylation using α-hydroxyl diazo compounds as versatile electrophiles.
Authors
- H. Eric Xu (ORCID: https://orcid.org/0000-0002-6829-8144)
- X. Liu
- Jiayin Li (ORCID: https://orcid.org/0000-0001-6825-0418)
- Xinlong Zhou
- Jinghan Zhang (ORCID: https://orcid.org/0000-0001-6841-4902)
- Jingjing Zhao
- Pan Li
- Nan Huang
- Jingjing Jiang
Institutions
- Henan University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1039/d5cc07167d
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 22.95