Synthesis of phosphonate derivatives via Fe3O4/ZnO MNPs: Investigation of antioxidant ability

A novel and efficient procedure for the generation of quinazolinone phosphonate derivatives employing the reaction of euparin, isatin or its derivatives, primary amines, dialkyl acetylenedicarboxylates, trimethyl phosphite or triphenyl phosphite and acidic solution of hydrogen peroxide in aqueous media at ambient temperature under ultrasonic irradiation was developed. Without ultrasonic irradiation the reaction does not proceed and agitation of the reaction mixture is difficult. In addition, the power of some prepared compounds as antioxidant was studied using trapping of radical by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and ferric reduction activity potential (FRAP) experiment. Some advantages of this procedure are: short time of reaction, high yields of product, easy isolation of products.